NEPHROPROTECTIVE EFFECT OF CUMINUM CYMENUM ON CHLOROPYRIFOS INDUCED KIDNEY OF MICE

Environmental pollution from pesticides is an important issue that attracts wide spread public concern. Among these organophosphate pesticides are routinely used in agriculture. Chloropyrifos toxicity has been largely associated with irreversible inhibition of acetyl-cholinesterase resulting in accumulation of acetylcholine in the cholinergic receptors. Organochlorine insecticides, caused degeneration in mouse kidney due to oxidative stress. Cuminum cyminum has shown significant antioxidant activity in several test methods. Cumin seeds have been reportedly used for traditional treatment of toothache, dyspepsia, diarrhea, epilepsy and jaundice. Thus the present study is designed to evaluate nephroprotective potential of Cuminum cymenum on chloropyrifos induced kidney of mice. Chlorpyrifos administration at 6 mg/kg b.wt for 4 weeks was followed by the administration of aqueous seed extract of Cuminum cyminum for 8 weeks at 75 mg/kg b.wt. Urea, uric acid and creatinine were increased evidently after chloropyrifos exposure. Degeneration was observed in glomerulus and bowmen’s capsule. PCT and DCT were also degenerated to greater extent in chloropyrifos administered group of mice. Effective restoration was observed in urea, uric acid and creatinine in Cuminum cyminum administered group of mice. Glomerulus, Proximal convoluted tubule, distal convoluted tubules and bowmens capsule was also restored effectively in Cuminum cyminum administered group of mice. It is evident from study that Cuminum cyminum has effective nephroprotective potential against chloropyrifos toxicity on kidney of mice.