A systematic review of argument on the correlation between serum uric acid level and Parkinson' s disease

Objective To review the correlation between serum uric acid(UA) level and Parkinson’s disease(PD) based on the papers published from 2004 to 2014 at home and abroad, with an attempt to provide new ideas for the early diagnosis and disease evaluation of PD. Methods Major online database including PubMed, CNKI, and Wan Fang date bases were searched in March 2014.The key words we used are "uric acid" , "Parkinson’s disease" and so on. Results Totally 28 studies were enrolled, the analysis showed there were argument on the correlation UA and PD, the effect of uarthritis on PD and the effect of antiparkison drugs on UA. Conclusion It is testified in most studies that UA level is obviously lower in PD patients.The variation of UA perhaps affects the morbidity, condition and non-motor symptom among patients with PD. However, the studies are limited by the research methods、the public surveyed and other factors. Key words: Uric acid; Parkinson's Disease; Wearing-off fluctuation; Non-motor symptoms; Gout; Levodopa