SAT0335 CLINICAL COURSE OF ANKYLOSING SPONDYLITIS (AS) IN PREGNANCY: INTERIM DATA FROM PROSPECTIVE STUDY

Objectives To study the dynamics of clinical signs, AS activity and patients’ functional status during gestation. Methods 19 pregnant females with confirmed AS based on modified NY criteria (1984) were included. Patients’ mean age was 32,2±1,1y., mean age at AS onset was 22,6±3,1 y., mean disease duration was 147±20,7 months. Control visits were scheduled at 10-11, 20-21 and 31-32 weeks of pregnancy. BASDAI and ASDAS-CRP calculators were used to assess AS activity, while patients’ functional status was assessed using BASFI and BASMI scores, and MASES score was used for evaluation of enthesitis. Results Pregnancy outcomes included 18 full-term births at 37,6±1,1 weeks of gestation, and a non-developing pregnancy at 18 weeks in one case. Newborns’ weight – 3518±67 g. Inflammatory low back pain at conception was reported by 78,9% of participants with mean pain intensity 2,2±0,4 scores by NRS. Pain during pregnancy was observed in 95% of all patients, its’ intensity increased by the II trimester (4,6±0,7) and persisted at the same level in the III trimester (p BASDAI score was increasing from the moment of conception (1,7±0,3) until the II trimester (3,3±0,5, p 0,05). BASMI score insignificantly changed during all 3 trimesters (1,3±0,9; 1,8±0,2; 2,1±0,3 – in I, II and III trimesters, correspondingly). BASFI score showed increase by the III trimester (3,9±0,7) as compared to I trimester (1,4±0,3, p Conclusion AS clinical activity increases by the II trimester of pregnancy and persists at moderate and high levels afterwards during all gestation period. AS activity at conception can predetermine AS activity during all pregnancy. 50% of pregnant patients are likely to experience low back pain in the III trimester due to increasing pressure of a growing fetus on the spine. Functional disability increases with progress in pregnancy, being caused in the III trimester by both – AS activity and pregnancy per se. Disclosure of Interests None declared