Synthesis and pharmacological evaluation of novel potential ultrashort-acting beta-blockers.
2003
The basic relationship between chemical structure and pharmacological activity of eight newly developed potential ultrashort-acting β-adrenergic blockers was evaluated. The compounds studied are derivatives of arylcarbonyloxyaminopropanols and were prepared by four-step synthesis. All the compounds evaluated showed weak antiisoprenaline (β-adrenergic receptor blocking) activity and antiarrhythmic (antiouabain) activity.
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