Synthesis and Biological Evaluation of Hydrazide based Sulfonamides

The purpose of present research is to synthesize hydrazide based sulfonamides due to their extraordinary potential in biology and medicine. The characterization of synthesized compounds was done by melting points, elemental analysis and spectroscopic techniques like I.R. Finally their antioxidant, enzyme inhibition and antimicrobial activity have been done. Sulfonamide (3a) shows maximum enzyme inhibition activity, similarly this sulfonamides shows maximum ferric reducing antioxidant power and free radical scavenging activity. Moreover, Synthesized sulfonamides 3a has antibacterial against E. coli and Candida albicans while compounds 3b shows antibacterial against Typhimusium Salmonella and Staphlococcus aureus furthermore 3c shows antibaceterial against Bacillus Subtilis, Staphlococcus aureus and Candida albicans.