The effect of intracranial hypotension on cerebral blood flow in a feline model

Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to −15 torr for several hours to −80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension.