A Dose-Finding, Placebo-Controlled Study of Extended-Release Felodipine Once Daily in Treatment of Hypertension

Hypertensive patients received a β-blocker plus placebo once daily for 4 weeks. If their diastolic blood pressure (DBP) was then 95-115 mm Hg, they were randomized to receive, in addition to the β-blocker, placebo, felodipine-extended release (ER) 10 mg, or felodipine-ER 20 mg in a 4-week double-blind parallel-group trial