Clinical immunological diagnostics of overlap syndrome during autoimmune hepatic disorders

Summary Th e complex determination of serum autoantibodies to hepatic antigens using enzyme immunoassay and immunoblot allows to increase the frequency of overlap syndrome identifi cation during autoimmune hepatic disorders and its early diagnostics, that has a big clinical, diagnostic and prognostic importance. Th e levels of overlap autoantibodies combine with biochemical index and with disease activity and intensity of autoimmune processes during overlap syndrome of primary biliary cirrhosis / autoimmune hepatitis (PBC / AIH).