Percutaneous absorption of methylprednisolone aceponate after single and multiple dermal application as ointment in male volunteers

Six healthy, elderly volunteers were treated once daily with Advantan ® oitment containing 0.1% of methylprednisolone aceponate (MPA, CAS 86401-95-8) in an area dose of 5 mg oitment/cm 2 on a marked area of 80 cm 2 of intact skin on the back for 14 days. The oitments used for treatment on days 1 and 8 contained 14 C-MPA with a specific radioactivity of 2.5 MBq/mg MPA