Proadhesive Cytokine Immobilized on Endothelial Proteoglycan

Inflammation and normal immune responses depend on the recruitment of specific leukocyte populations. Similarly, the maturation of lymphocytes requires their trafficking from blood into the appropriate lymphoid organ at the correct time. These processes require that leukocytes bind to endothelium in a specific and selective fashion, i.e., the right leukocyte subpopulation at the right time and place. In recent years, it has become apparent that numerous molecules are involved in this process. During the last year a consensus view has emerged, based on cumulative contributions from many laboratories, which proposes that leukocytes interact with endothelium by a multistep process involving several different classes of adhesion molecules. This model, which is the starting point for the present analysis, has been reviewed in detail elsewhere (Dustin and Springer, 1991; Shimizu et al., 1992; Butcher, 1991; Zimmerman et al., 1992; Pardi et al., 1992; Schweighoffer and Shaw, 1992b), and will be restated here only briefly, as it pertains to T cells.