Some pathways to overcoming drug resistance of influenza a virus to adamantane derivatives

Aseries of adamantane derivatives incorporating amino-acid residues have been synthesized for the first time and their antiviral activity with respect to influenza Avirus subtypes A(H1N1)v and A(H3N2) has been studied. It is established that some of the synthesized compounds can inhibit influenza A virus strains resistant to rimantadine. Thus, restoration of the antiviral activity of rimantadine with respect to resistant influenza strains is possible.