Influence of Xuejie(Risina Draconis)combining Diyu(Radix Sanguisorbae)on mucosal healing of ulcerative colitis

Objective To review the curative effect of local retention enema of Xuejie(Risina Draconis) combining Diyu(Radix Sanguisorbae) on mucosal healing of ulcerative colitis(UC) observed with endoscope.Methods UC patients(n=59) were randomly divided into treatment group(n=30) and control group(n=29).Two groups were treated with 5-aminosalicylic acid(5-ASA,3 g/d) for 4 weeks,and treatment group was additionally given retention enema of Xuejie combining Diyu.The changes of disease active index(DAI) and endoscope scores were compared between two groups before and after the treatment.Results after treatment for 4 weeks,DAI was lower in treatment group than that in control group but the difference was not significant(t=2.34,P0.05),and remission rate observed with endoscope was increased in treatment group and the difference was significant(t=1.78,P0.05) between two groups.Conclusion The local retention enema of Xuejie combining Diyu can improve mucosal healing observed with endoscope and it is an effective adjuvant therapy for treating UC.