Treatment of Mycobacterium avium-intracellulare Complex Infection in Beige Mice with Free and Liposome-Encapsulated Streptomycin: Role of Liposome Type and Duration of Treatment

Current treatments for Mycobacterium avium-intracellulare complex (MAC) infections are generally ineffective. Thus, the potential of free or liposome-encapsulated streptomycin to treat acute MAC infection was investigated in beige mice. Free streptomycin administered intramuscularly 5 days a week (150 mg/kg) was effective in the liver, spleen, and lungs