Impact of the Intima Dynamic Motion in Type B Acute Aortic Dissection on Renal Injury: Quantificationally Assessed by Dose-Regulated Retrospective ECG-Gated Dual-Source CT Angiography

Background Little is known about the influence of intima dynamic motion on organ ischemia and related outcomes. The purpose of this study is to quantitatively evaluate intima oscillation by CT angiography (CTA), determine its impact on acute kidney injury (AKI) in patients with type B acute aortic dissection (TB-AAD) before thoracic endovascular aortic repair (TEVAR), and further analyze its association with early adverse events postoperatively. Methods Totally, 108 patients with TB-AAD who underwent retrospective ECG-gated CTA and received TEVAR were enrolled. Patients were divided into AKI and non-AKI groups. Area of the true lumen (TLA) was computed at R–R intervals at the upper level of kidney vessel origin every 5% step from 0% to 95%. Additionally, other morphologic parameters that have been identified as risk predictors for adverse events in uncomplicated TB-AAD were evaluated. Results Forty-three (39.8%) patients were sorted into the AKI group. Patients with AKI exhibited a larger value for the relative change of TLA (C rel -TLA) than patients in the non-AKI group ( p p  = 0.023) and the primary entry tear ( p  = 0.012). C rel -TLA and elevated systolic blood pressure were independent predictors of AKI. Patients with C rel -TLA ≥ 42.6% were associated with a high incidence of renal ischemia before TEVAR and early adverse events postoperatively (all p Conclusion Intima dynamic motion, as quantitatively evaluated by CTA, has a significant influence on renal injury before and after the aortic intervention, as well as other adverse events, which might guide clinical therapy in high-risk patients.