Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

Abstract The production capability of a fermentation process is predominately determined by individual strains, which are ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains. Interpreting these complicated interactions is key for better understanding the scale-up of the fermentation process. We review these two aspects and address progress in strategies for scaling up fermentation processes. A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes.