Experience-dependent changes to cortico-hippocampal networks during NREM sleep

Memory reactivation during NonREM-ripples is thought to communicate new information to a systems-wide network. We now show a learning-specific increase in cortical ripple power associated with decreased hippocampal power across a hippocampal-prefrontal-parietal network, and increases in connectivity measured by Granger Causality. Disruption of either sleep or ripples impairs long-term memory consistent with a role for these ripples in memory consolidation.