The long observation in vitro of prevention effect of novel self-etching orthodontic adhesive modified with 2-methacryloxyethyl phosphorylcholine in enamel demineralization.

The enamel demineralization is common in fixed orthodontics. Plaque accumulation around the bracket plays a critical role and could cause various degrees of white spot lesions (WSLs) on the surface of teeth. The 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer is a biological polymer with protein repellent and an anti-bacterial adhesion effects. In this study, the enamel shear bond strength (SBS) and protein repellent property in vitro of self-etching orthodontic adhesive with MPC were evaluated. It was found that the self-etching adhesive with 0-7.5%MPC met the orthodontic clinical requirement on the SBS values at three different points of time, The incorporation of 7.5%MPC significantly reduced the bacterial adhesion and total microorganism of the yield biofilm. Moreover, the MTT assay showed that the amount of plaque metabolism in 7.5%MPC was the lowest among the groups. To conclude, the novel protein repellent self-etching adhesive was able to inhibit biofilm formation efficiently and minimize enamel demineralization.