The method of proliferation plasma cells

Virus infected cells, cancer cells, to facilitate the acquisition of antibody-producing cells infiltrating such abnormal cells constituting benign hyperplasia, production of nucleic acid encoding the antibody and then the antibody-producing cells more efficiently an object of the present invention is to. T cell, B cell, no NK cell, and a highly immunodeficient animals exhibiting low IFN-producing ability, when transplanting cancerous tissue containing infiltrating lymphocytes, differentiation and proliferation of infiltrating lymphocytes prompted unexpectedly the number of plasma cells producing antibodies that recognize the cancer tissue is increased dramatically, the plasma cells can be easily separated, and further found that a nucleic acid encoding an antibody or antibody from the plasma cells may be readily prepared It was.