Carbamate-appended N-alkylsulfonamides as inhibitors of γ-secretase

Abstract The synthesis and γ-secretase inhibition data for a series of carbamate-appended N -alkylsulfonamides are described. Carbamate 54 was found to significantly reduce brain Aβ in transgenic mice. 54 was also found to possess markedly improved brain levels in transgenic mice compared to previously disclosed 1 and 2 .