Pulsatile secretion of luteinizing hormone and sleep-related gonadotropin rhythms in girls with premature thelarche

The concentrations of LH, FSH and PRL were determined in serum samples obtained at night in 1–2 h intervals as well as at 15 min intervals during a 3 h period between 9 and 12 p.m. and 9 and 12 a.m. in three girls with premature thelarche, who had not developed further signs of precocious puberty for more than 18 months.