ɇɈВЫɃ ɄАɌɂɈɇɇЫɃ ɉУɊɉУɊɂɇɂɆɂȾ ȾɅə ɎɈɌɈȾɂɇАɆɂЧȿɋɄɈɃ ɂɇАɄɌɂВАɐɂɂ ȻɂɈɉɅȿɇɈɄ PSEUDOMONAS AERUGINOSA 1 Ɇоɫкоɜɫкиɣ ɝоɫɭɞаɪɫɬɜеɧɧыɣ ɭɧиɜеɪɫиɬеɬ ɬоɧкиɯ ɯиɦиɱеɫкиɯ ɬеɯɧоɥоɝиɣ иɦеɧи Ɇ .ȼ. Ʌоɦоɧоɫоɜа , Ɇоɫкɜа 2 Ɏеɞеɪаɥɶɧыɣ ɧаɭɱɧо-иɫɫɥеɞоɜаɬеɥɶɫкиɣ цеɧɬɪ ɷɩиɞеɦиоɥоɝии и ɦикɪоɛиоɥоɝии иɦ . ɩоɱеɬɧоɝо акаɞеɦика ɇ .Ɏ .

Abstract New cationic photosensitizer for photodynamic antibacterial chemotherapy based on Chremophor dispersion of using methyl ester 13 3 - N -( N -methylnicotinyl) purpurinimide was developed. It was shown the complete photodynamic inactivation of bacteria Pseudomonas aeruginosa biofilms by using new photosensitizer at the concentration of 1 mM, the incubation time of 1 hour and the irradiation dose of 105 J/cm 2 . Key words: biofilms, photosensitizer, photodynamic inactivation, purpurinimide. Вв рgbq_kdb_ bgn_dpbb, яаы kh kih-kh[ghklvx iаlhы ар d h[раhаbx л , яляxlя k_р_aghc f_^bpbgkdhc р -л . аралы л раля kh[hc ра\аы khh[а арbc h^gh]h л л \b^h\, hdру`_ggы_ эhлр -ы арbdkhf, dhlhрыc аа аdl_рbb hl \hя аlb[bhlbdh\ b арh\ у аы ohяа [7]. Hkh[hc уcqb\hklvx ла -а [bл раlралы ар Pseudomonas aeruginosa