Liposome-Encapsulated Hemoglobin Transfusion Rescues Rats Undergoing Progressive Hemodilution From Lethal Organ Hypoxia Without Scavenging Nitric Oxide

Objective:To investigate the efficacy of liposome-encapsulated hemoglobin (LHb) transfusion in rats undergoing lethal progressive hemodilution.Summary Background Data:Unlike other acellular hemoglobin-based oxygen carriers, LHb has lipid bilayer membranes that are similar to mammalian red blood cell