The methods of in vitro selection of chemotherapeutic druds for individual chemotherapy of maligant tumors in patinets

The review considers methods for selecting chemo- and biopreparations, their combinations using 2D and 3D cell culture models to predict a personified response of patients with malignant neoplasms (ovarian, stomach, intestine, lung, lacteal, pancreas, head and neck cancer) to chemotherapy. Performance indicators (sensitivity, specificity, prolongation of total and disease-free survival) of chemosensitivity assessment methods in cultures of tumor cells are analyzed on the basis of their comparison with the effectiveness of chemotherapy of patients. The article highlights the advantages and disadvantages of the methods described, the prospects for their further application in clinical practice.