Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia

Yeguang Hu,Zhihong Zhang,Mariko Kashiwagi,Toshimi Yoshida,Ila Joshi,Nilamani Jena,Rajesh Somasundaram,Akinola Olumide Emmanuel,Mikael Sigvardsson,Julien Fitamant,Nabeel El-Bardeesy,Fotini Gounari,Richard A. Van Etten,Katia Georgopoulos

Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia

2016

Yeguang Hu
Zhihong Zhang
Mariko Kashiwagi
Toshimi Yoshida
Ila Joshi
Nilamani Jena
Rajesh Somasundaram
Akinola Olumide Emmanuel
Mikael Sigvardsson
Julien Fitamant
Nabeel El-Bardeesy
Fotini Gounari
Richard A. Van Etten
Katia Georgopoulos

IKAROS is required for the differentiation of highly proliferative pre-B-cell precursors, and loss of IKAROS function indicates poor prognosis in precursor B-cell acute lymphoblastic leukemia (B-AL ...

Keywords:

Genetics
Developmental biology
Leukemia
Reprogramming
Lymphoblastic Leukemia
B cell
Biology
poor prognosis
YAP1
PRC2
Immunology

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