Белковый оксидативный стресс при сочетанной респираторно-кардиальной коморбидности

In the paper we have studied the activity of peroxide oxidation of proteins according to the level of carbonyl derivatives in patients with chronic obstructive pulmonary disease (35 patients), ischemic heart disease (35 patients), arterial hypertension (35 patients), and combined respiratory cardiac pathology: chronic obstructive pulmonary disease + ischemic heart disease (40 patients) and chronic obstructive pulmonary disease + arterial hypertension (40 patients). It has been proved that comorbid ischemic heart disease in patients with chronic obstructive pulmonary disease is associated with an increased activity of processes of protein peroxidation, the active peroxidation of protein molecules leading to endothelial dysfunction with hypersecretion of vasoconstrictors. In the group of patients with the combination of chronic obstructive pulmonary disease + ischemic heart disease we have found a correlation between the level of carbonyl derivatives and the level of endothelin-1 (r=0.613 p<0.001), that confirms our conclusion.