Synthesis, Hammett spectral correlation and biological evaluation of some substituted (E) 1-hydroxy-2-naphthyl chalcones

A series of some substituted (E)-1-(1-hydroxynaphthalen-2-yl)-3-phenylprop-2-en-1-oneshave been synthesized by microwave assisted Silica- H3PO4catalyzed green Crossed-Aldol condensation of 1-hydroxy-2-acetylenaphthone and substituted benzaldehydes. These chalcones were characterized by their physical constants and spectral data. From IR and NMR spectra, the spectral frequencies of vCOs-cis and s-trans, deformation modes of νCHip, νCHop, νCH=CHop and νC=Cop(cm-1), δH and δC of α, β and CO (ppm) of synthesized chalcones were correlated with Hammett substituent constants, F and R parameters. From the results of statistical analyses the effects of substituents on the group frequencies have been discussed. The antimicrobial activities of all chalcones have been studied using Bauer-Kirby method.