Vitamin D: a custodian of cell signalling stability in health and disease
2015
There is increasing evidence that a deficiency in vitamin D contributes to many human diseases such as Alzheimer9s disease (AD), Parkinson9s disease (PD), multiple sclerosis (MS), hypertension and cardiovascular disease. The ability of vitamin D to maintain healthy cells seems to depend on its role as a guardian of phenotypic stability particularly with regard to the reactive oxygen species (ROS) and Ca 2+ signalling systems. Vitamin D maintains the expression of those signalling components responsible for stabilizing the low-resting state of these two signalling pathways. This vitamin D signalling stability hypothesis proposes that vitamin D, working in conjunction with klotho and Nrf2 (nuclear factor-erythroid-2-related factor 2), acts as a custodian to maintain the normal function of the ROS and Ca 2+ signalling pathways. A decline in vitamin D levels will lead to an erosion of this signalling stability and may account for why so many of the major diseases in man, which have been linked to vitamin D deficiency, are associated with a dysregulation in both ROS and Ca 2+ signalling.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
108
References
25
Citations
NaN
KQI