EFFICACY OF NARROWBAND ULTRAVIOLET B 311 NM PLUS AN INHIBITOR OF PHOSPHODIESTERASE 4 (PDE4) COMBINED THERAPY IN PATIENTS WITH MODERATE TO SEVERE PLAQUE PSORIASIS

Objective. to determine the effectiveness and tolerability of narrowband ultraviolet (UV) B (311 nm) plus an inhibitor of phosphodiesterase 4 (PDE4) combined therapy in patients with moderate to severe plaque psoriasis. Material and methods. the first group consisted of 30 patients (18 women and 12 men) who were treated with UVB 311 nm and inhibitor of phosphodiesterase 4 (PDE4). The second (control) group was treated with UVB 311 nm and methotrexate (n = 30; 15 women and 15 men). The study participants were aged 32 to 67 (43.8 ± 4.34). Results. it was determined greater efficiency (PASI 100 43.3% of patients and PASI 90 46.7%) of the treatment plaque moderate to severe psoriasis patients with UVB 311 nm plus an inhibitor of PDE4 compared to UVB 311 nm plus methotrexate (PASI 100 10% of patients and PASI 90 40%). The treatment was well-tolerated. The side effects in both groups were mild, did not require the cancellation of the prescribed treatment regimen, and were often stopped on their own or with minimal corrective therapy.