Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

A. A. Spasov,Alexander N. Geisman,Vadim A. Kosolapov,Denis A. Babkov,A. I. Rashchenko,V. A. Babkova,O. Yu. Zakhar’yashcheva,Alexander Ozerov

Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

2019

A. A. Spasov
Alexander N. Geisman
Vadim A. Kosolapov
Denis A. Babkov
A. I. Rashchenko
V. A. Babkova
O. Yu. Zakhar’yashcheva
Alexander Ozerov

S-carboxyalkyl derivatives of 2-thiouracil were synthesized and their pharmacological activity was studied. Several of the compounds were characterized by antiglycation activity. These compounds had no effect on PPAR or glucokinase activity and had weak activity in cleaving protein crosslinks.

Keywords:

Glucokinase
Chemistry
Organic chemistry
Thiouracil
Biochemistry
pharmacology toxicology
Glucokinase activity
Biological activity

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