РАЗВИТИЕ ТОКСИКОЛОГИЧЕСКОЙ ТОЛЕРАНТНОСТИ К ИЗОНИАЗИДУ В УСЛОВИЯХ ЭКСПЕРИМЕНТА

Results of experimental studies are reported that made it possible to establish decrease in sensitivity and the development of toxicological tolerance (addiction) to the anti-tuberculosis drug “Isoniazid” repeatedly administered to laboratory animals in toxic doses and to determine growth rate of the toxicological tolerance development, maximum and average life expectancy, severity of seizures .