PerspectivesTrials without tribulations: Minimizing the burden of pragmatic research on healthcare systems

Pragmatic clinical trials are increasingly common because they have the potential to yield findings that are directly translatable to real-world healthcare settings. Pragmatic clinical trials need to integrate research into clinical workflow without placing an undue burden on the delivery system. This requires a research partnership between investigators and healthcare system representatives. This paper, organized as a series of case studies drawn from our experience in the NIH Health Care Systems Research Collaboratory, presents guidance from informational interviews of physician–scientists, health services researchers, and delivery system leaders who recently launched pragmatic clinical trials.