A new epoxidic ganoderic acid and other phytoconstituents from Ganoderma lucidum

Abstract A new epoxidic ganoderic acid, 8α,9α-epoxy-3,7,11,15,23-pentaoxo-5α-lanosta-26-oic acid ( 1 ), together with the known compounds 3β-hydroxy-7,11,15,23-tetraoxo-5α-lanosta-8-en-26-oic acid ( 2 ), ergosta-7,22-diene-3β-yl pentadecanoate ( 3 ), ergosta-7,22-diene-3β-ol ( 4 ), β-sitosterol ( 5 ), fatty acids ( 6 – 10 ), fatty acid ester ( 11 ) and octadecane ( 12 ) were isolated from the fruiting bodies of Ganoderma lucidum from south India. Their structures were determined by 1 H, 13 C, 13 C DEPT, 1 H– 1 H COSY, HMBC, HSQC, NOESY NMR, FT-IR, UV–vis and FABMS spectral analysis. Compounds ( 1 – 3 ) exhibited good antifungal activity against Candida albicans in disc diffusion assay (100 μg/disc). Steroid ester ( 3 ) showed moderate anti-inflammatory activity (59.7% inhibition, 100 mg/kg body weight) in carrageenan-induced paw edema.