[Effects of proton pump inhibitors on in-stent restenosis in patients receiving clopidogrel: a retrospective analysis].

Objective: To determine the effect of proton pump inhibitor(PPI) on in-stent restenosis(ISR) in patients receiving clopidogrel therapy. Methods: Total 439 patients underwent percutaneous coronary intervention(PCI) were enrolled in the study,including 250 post-PCI patients discharged on clopidogrel alone and 189 patients discharged on clopidogrel with PPI.The in-stent restenosis(ISR) ratio of the patients in these two groups were observed. Results: During a mean follow-up period of(13±5.9) months,the post-PCI patients discharged on concomitant clopidogrel-PPI therapy had higher risk of ISR than those discharged on clopidogrel alone(19.6% vs 8%,P0.001). Conclusion: Concomitant use of clopidogrel and PPI after hospital discharge would increase the risk of ISR for post-PCI patients.