Sustained-release formulation having a bone conduction function

The present invention, osteoclastogenesis inhibitory factor, its the analogs or variants, or modified form thereof, a sustained release formulation comprising porous particles comprising calcium phosphate and the nanocrystals and polysaccharides, the osteoclasts formation inhibitor, characterized in that the entire inner pore surface of its analogs or variants, or modified form thereof wherein the porous particles are bonded via a divalent metal ion, broken excellent osteoconductive regarding the sustained-release preparation of the bone cell formation inhibitory factor OCIF / OPG.