Synthesis and antibacterial evaluation of several novel tripod pyrazoline with triazine core (TPTC) compounds

A series of new thiocarbamoyl tris-pyrazoline (tripod pyrazoline with triazine core) compounds was obtained by tris-cyclization of chalcone with thiosemicarbazide under basic condition in dry dimethylformamide (DMF) as solvent. Tris-chalcones were prepared by condensation of tris-acetophenone and appropriate aldehydes in basic medium. The newly synthesized compounds were completely identified. The antibacterial activity of the tris-pyrazolines and tris-chalcones was evaluated against Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. Biological data indicated that these compounds are effective against these bacteria.