Prevalence of in‐hospital nonsteroidal antiinflammatory drug exposure in patients with a primary diagnosis of heart failure
2017
AbstarctAim
To determine the prevalence of in-hospital non-steroidal anti-inflammatory drug (NSAID) exposure and associated outcomes in patients admitted with a primary diagnosis of heart failure.
Methods: We performed a propensity-matched cohort analysis of patients admitted to Houston Methodist Hospital System with a primary diagnosis of heart failure according to the International Classification of Diseases–9–Clinical Modification (ICD-9-CM) from January 1st 2011 to December 31st 2014.
Results
Of the 9742 patients admitted with a primary diagnosis of heart failure, 384 patients (3.9%) were exposed to NSAID. After applying propensity scores we matched 305 NSAID exposed with 915 unexposed patients. Patients with in-hospital NSAID exposure had a longer length of stay (7.0 ± 8.8 days vs 6.1 ± 8.5; p = 0.003) and increased prevalence of worsening renal function (34.4% vs 27.9%; p = 0.030). There were not statically significant differences in in-hospital mortality rate or 30-day all cause readmission rate.
Conclusion
Exposure to NSAID in patients admitted with a primary diagnosis of heart failure was low but was associated with adverse outcomes including longer length of stay and higher prevalence or worsening renal function.
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