Prevalence of in‐hospital nonsteroidal antiinflammatory drug exposure in patients with a primary diagnosis of heart failure

AbstarctAim To determine the prevalence of in-hospital non-steroidal anti-inflammatory drug (NSAID) exposure and associated outcomes in patients admitted with a primary diagnosis of heart failure. Methods: We performed a propensity-matched cohort analysis of patients admitted to Houston Methodist Hospital System with a primary diagnosis of heart failure according to the International Classification of Diseases–9–Clinical Modification (ICD-9-CM) from January 1st 2011 to December 31st 2014. Results Of the 9742 patients admitted with a primary diagnosis of heart failure, 384 patients (3.9%) were exposed to NSAID. After applying propensity scores we matched 305 NSAID exposed with 915 unexposed patients. Patients with in-hospital NSAID exposure had a longer length of stay (7.0 ± 8.8 days vs 6.1 ± 8.5; p = 0.003) and increased prevalence of worsening renal function (34.4% vs 27.9%; p = 0.030). There were not statically significant differences in in-hospital mortality rate or 30-day all cause readmission rate. Conclusion Exposure to NSAID in patients admitted with a primary diagnosis of heart failure was low but was associated with adverse outcomes including longer length of stay and higher prevalence or worsening renal function. This article is protected by copyright. All rights reserved.