Correlation study of high-sensitivity C-reactive protein, D-dimer, left atrial diameter with cardiac function in patients with non-valvular atrial fibrillation

Objective To investigate the correlation of high-sensitivity C-reactive protein,D-dimer,left atrial diameter with cardiac function in patients with non-valvular atrial fibrillation (NVAF).Methods Sixty-five patients with non-valvular atrial fibrillation were chose as test group,and 55 patients without atrial fibrillation were chose as control group.Their ages,levels of FPG,TC,TG,hs-CRP,D-dimer,LAD and LVEF were recorded.Results The ages,levels of hs-CRP,D-dimer,and LAD were higher in test group than those in the control group,and the level of LVEF was lower in test group than that in the control group (P＜0.05).In test group,the LVEF was negatively correlated with age(r =-0.196),hs-CRP (r =-0.486),D-dimer(r =-0.209),LAD (r =-0.741),P ＜ 0.05.Age,hs-CRP,D-dimer,LAD were the influencing factors of cardiac function of patients with non-valvular atrial fibrillation.Conclusions Advanced age,inflammatory factor,fibrinolytic system factor and cardiac structural modification probably can lead to the decline of cardiac function in patients with non-valvular atrial fibrillation. Key words: Non-valvular atrial fibrillation ;  High-sensitivity C-reactive protein;  D-dimer;  Left atrial diameter;  Left ventricular ejection fraction