Zolimidine Analogues: The Synthesis of Imidazo[1,2-α]pyridine-Based Sulfilimines and Sulfoximines

Zolimidine is a methylsulfonyl-substituted drug with an imidazo[1,2-α]pyridine core used for the treatment of peptic ulcer. Herein, we report the synthesis of unprecedented N -acetylsulfilimine and -sulfoximine­ analogues under mild conditions. Deprotection of the N -acetylsulfoximine allows the preparation of the corresponding NH-sulfoximine.