Positional Scanning for Peptide Secondary Structure by Solid Phase Synthesis with Aza-Amino Acids and Freidinger Lactams

Introduction Positional scanning for the importance of structure for activity is fundamental for advancing peptide science. For example, the structural biology of a peptide may be ascertained using Ala, Pro and D-amino acid scans to provide information on the importance of side-chains, conformation and configuration for activity. Two new methods for positional scanning are being developed in our laboratory. “Azascanning” and “lactam-scanning” employ respectively, aza-amino acids and Freidinger lactams to study the importance of turns for peptide activity.