Effect of botulinum toxin type A in the contraction of lesions treated with full-thickness grafts

Background The treatment of traumatic injuries and burns presenting tissue loss—which are called full-thickness wounds—is primarily accomplished with skin grafts. This, however, remains an ongoing challenge because grafts have a number of limitations, perhaps being the secondary contraction determining movement restriction due to graft contracture, the main one. In this context, the currently available treatments are—in many cases—insufficient, and thus, the search for new alternatives is necessary. The objective was to evaluate the effect of botulinum toxin type A (in different doses) in the contraction of full-thickness wounds treated with full-thickness grafts.