The influence of decoction with function of nourishing kidney and promoting blood flow to model rat of fetal loss induced by APA.

Objective:To explore the influence ofDan Shou Tang to fetal loss induced by APA.Methods:One hundred of10-week pregnant SD rats were divided randomly into two groups, every group were divided randomly into nourishing kidney and promoting blood flow group A, nourishing kidney group B, promoting blood flow group C, group D-APS model group and group E--blank control group.From the first day ofpregnancy, the rats in group A were given Dan Shou Tang through intragastric administration;the rats in group B were given formula to nourish kidney and rats in group C were given formula to promote blood flow, while group D and group E, as the control were given the corresponding physiological brine through intragastric administration.Then on the eighth and the twelfth day ofpregnancy, all rats ofgroup A, B, C and D were given multi-site subcutaneous injecting ofpurified ACA-IgG or LA-IgG with a dosage of15mg/ml, fats ofgroup E were injected the corresponding physiological brine.On the 15th day ofpregnancy, the rats were killed for samples.Results:Compared with APS model group, fetal absorptivity, ACA and APTT level were dramatically decreased in group A, B and C(P0.01), and pathological observation ofplacenta showed obvious improvement;fetus weight was dramatically increased in group A andC,(P0.01,P0.05);Dan Shou Tang showed the most significant effect among group A , B and C(P0.05).Conclusion:The formula with function ofnourishing kidney and promoting blood flow has positive clinical efficacy in decreasing APA level, fetal absorptivity and increasing fetus weight and pregnancy chances.