L-histidine production method and special recombinant bacteria
2014
The invention discloses an L-histidine production method and special recombinant bacteria. The present invention provides a method to construct the recombinant bacteria, and the method includes the following steps: the recombinant bacteria is obtained by reduction of expression of 6-phosphate glucose isomerase in starting strain and improvement of expression of 6-phosphate glucose dehydrogenase and PRPP (phosphoribosyl pyrophosphate) synthetase in the starting strain, the beneficial effects are that an new L-histidine fermentation yield improvement method is disclosed and proved, the effects of stack to increase yield is observed, and in practice, the L-histidine production method can be used for bacterial fermentation production of L-histidine, and is convenient to popularize and apply.
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