Синтез некоторых производных 2-аминотиазола

The optimum amount of urea for the selective bromination of ketones in DMF has been established. The obtained α-bromoketones have been used for the synthesis of 2-aminothiazoles in situ. A series of compounds with potential biological activity have been synthesized proceeding from chloroacetyl derivatives of 2-aminothiazoles.