Vacuolation toxin-neutralizing agent

The present invention, fewer side effects, without the occurrence of resistant bacteria, the prevention of gastrointestinal diseases Helicobacter pylori is involved, pharmaceuticals having a sterilizing effect of relapse prevention or treatment and Helicobacter pylori, quasi-drugs or food to provide the goods. Proanthocyanidins having the effect of Helicobacter pylori to neutralize vacuolation toxin produced (detoxification), particularly preferably contains proanthocyanidins derived from unripe apple or hop bract as an active ingredient, pharmaceutical, pharmaceutical unit outside products, to provide food and drink.