Improved Method for the Synthesis of β-Carbonyl Silyl-1,3-dithianes by the Double Conjugate Addition of 1,3-Dithiol to Propargylic Carbonyl Compounds.

Sumit Mukherjee,Dimitra Kontokosta,Aditi Patil,Sivakumar Rallapalli,Daesung Lee

Improved Method for the Synthesis of β-Carbonyl Silyl-1,3-dithianes by the Double Conjugate Addition of 1,3-Dithiol to Propargylic Carbonyl Compounds.

2010

Sumit Mukherjee
Dimitra Kontokosta
Aditi Patil
Sivakumar Rallapalli
Daesung Lee

Base-mediated double conjugate addition of 1,3-propane dithiol to various silylated propargylic aldehydes and ketones allows for an efficient and scalable synthesis of β-carbonyl silyl-1,3-dithianes.

Keywords:

Medicinal chemistry
Addition reaction
Conjugate
Silylation
Dithiol
Chemistry
Organic chemistry
improved method

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