Novel UPLC ® Columns for the Analysis of Synthetic Cannabinoids and Metabolites in Whole Blood for Forensic Toxicology

Extraction recoveries ranged from 73 to 105% with an average of 92% and matrix effects were less than 20% for all compounds with only 3 greater than 15%. Calibration curves were linear from 2-500 ng/mL, with accurate and precise results from quality control samples. The analysis of several different classes of these drugs should render this method applicable to newly developed related compounds with little, if any, modification necessary.