Synthesis and biological evaluation of substituted indazolyl amide derivatives as S-adenosyl-l-homocysteine hydrolase inhibitors

Abstract A series of novel amide derivatives bearing an indazole moiety were synthesized and evaluated for their in vitro S -adenosyl- l -homocysteine hydrolase (SAHase) inhibitory activity. Among these compounds, 8b , 8m , 8r and 8w showed better or similar inhibitory effects compared to the positive control aristeromycin. These results provide a novel lead for the discovery of more potent non-adenosine analogs as SAHase inhibitors.