Die Tumorheterogenität des uvealen Melanoms: Diagnostisch und prognostisch wichtig?
2021
Tumor biopsies in uveal melanoma (UM) serve mainly the purpose of prognostication
and assessment of individual metastatic risk, but can be used for diagnosis in selected
cases. The importance of precise information is paramount for selecting adequate surveillance
protocols, patient counseling, and optimization of treatment strategies. However,
intratumoral heterogeneity and sample representativity are major concerns and can
interfere with the correct prediction of the patient’s prognosis. We report a series
of cases of UM with distinct morphologically identifiable areas, highlighting the
differences in clinical behavior, as well as histopathological and genetic features.
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