Assessment of Vascular Permeability in Calf with Dynamic Contrast MRI

Introduction Dynamic T1-weighted MRI in conjunction with Gd-DTPA is a promising method for investigating breakdown of the blood-brain barrier (1,2). In the lower extremities, most of dynamic contrast MRI studies have been devoted to detection of abnormal blood flow in major or peripheral vessels (3). The purpose of this study is to investigate the feasibility of dynamic contrast MRI for estimation of vessel permeability in calf muscle of healthy control.