Indanedione chiral cyclohexane spirocompound and preparation method and use thereof

The invention discloses an indanedione chiral cyclohexane spirocompound as shown in formula I or a crystal form, a pharmaceutically acceptable salt, a hydrate or a solvate thereof. In the formula, R1 and R2 are selected from aryl or substituted aryl respectively or simultaneously; and R3 is selected from hydrogen, C1-C6 alkyl or C1-C6 alkoxyl. The new compound as shown in formula I, disclosed by the invention, has an inhibition effect for one or more of colon bacillus, stenotrophomonas maltophilia, acinetobacter lwoffi, staphylococcus aureus and staphylococcus epidermidis, thereby providing a new choice for clinical screening of antibacterial, bacteriostatic and bactericidal medicaments.